Robert A. Petit III, PhD rpetit3

Our work provides greater insight into the diversity of Staphylococcus aureus isolates from cystic fibrosis patients, specifically the distribution of important virulence factors and their interaction with Pseudomonas aeruginosa, all of which have implications in patient health.

We report for the first time that the product of the carA gene is necessary for δ-toxin production in Staphylococcus aureus USA300.

The iron-regulated surface determinant (Isd) system scavenges heme-iron from the human host, enabling acquisition of iron in iron-deplete conditions in Staphylococcus aureus during infection. We describe the first isolation of fully human IsdA and IsdH monoclonal antibodies (mAbs), as well as cross-reactive Isd monoclonal antibodies (mAbs).

we present the whole-genome sequences of 65 Staphylococcus aureus isolates obtained from 50 individuals with cystic fibrosis.

Clonal lineages of methicillin-resistant Staphylococcus aureus USA300 may continue to colonize people at one or more anatomic sites up to a year after an initial infection and experience loss of the SCCmec, loss and gain of other mobile genetic elements, and mutations in the agr operon.

We present Staphopia, an analysis pipeline, database and application programming interface, focused on Staphylococcus aureus, a common colonizer of humans and a major antibiotic-resistant pathogen responsible for a wide spectrum of hospital and community-associated infections

We have developed a strategy for assignment Staphylococcus aureus USA500 strains, which are often confused with USA300, a closely related to the prominent community- and hospital-associated strain.

We developed a genome-based method for detecting Staphylococcus aureus subtypes from metagenome shotgun sequence data.

Our study also reveals households serve as long-term reservoirs of Staphylococcus aureus USA300 and household methicillin-resistant S. aureus (MRSA) eradication programs may result in a uniquely effective control method.

We report a genome-wide association study (GWAS) of vancomycin-sensitive Staphylococcus aureus (VSSA) and vancomycin-intermediate S. aureus